
Fixes looks at solutions to social problems and why they work.
Damon Winter/The New York TimesA health worker was disinfected after bringing cholera victims to a grave near Port-au-Prince, Haiti, in November 2010.Cholera is on the rise around the world. Last year, according to Unicef, West and Central Africa had “one of the worst ever” cholera outbreaks. An outbreak in Haiti sickened 1 in 20 Haitians and killed more than 7,000 people. The World Health Organization estimates that there are between three million and five million cases of cholera each year, and between 100,000 and 120,000 deaths. New and more virulent strains are emerging in Asia and Africa, and the W.H.O. says that global warming creates even more hospitable conditions for the disease.
In most parts of the world, the last few months have brought a respite. But April is the start of the rainy season, which is also the cholera season.
Cholera should not be a terror. It is easy to treat if you know how. Countries that live permanently with endemic cholera, like Bangladesh, see fewer than one death per 100 cases. But in recent epidemics in Zimbabwe, Somalia and Haiti, death rates in some areas have been reported at 10, 20 or even 50 percent. In countries unfamiliar with the disease, people don’t know the steps to take or have the tools they need.
With cholera, speed matters. It can kill very quickly — in a few hours if victims are already malnourished. And since the incubation period for the cholera bacteria can be as short as two hours, it spreads fast.
Until now, early action has been nearly impossible. Governments, fearing stigma and a loss of tourism, often cover up cholera, and international organizations sometimes go along with the fiction. Even when governments do call cholera by its name and start inviting international help and expertise, the W.H.O. and Unicef are bureaucracies — and such invitations can come weeks after a widespread epidemic is under way.
A new partnership between two organizations that battle cholera will make it possible to get supplies and knowledge to cholera-stricken areas much faster. Early next month, AmeriCares, a United States-based aid group that specializes in airlifting medical supplies into disaster zones, will finish assembling a group of pallets containing everything necessary to treat 15,000 cases of cholera.
AmeriCares says it can get those pallets from the assembly site in the Netherlands to anywhere in the world within 48 hours. The know-how will be brought — also at top speed — by doctors and nurses from the International Center for Diarrheal Disease Research, Bangladesh, the world’s leading cholera experts. Instead of waiting for an invitation from a government or international organization, the center will bring the medical help in right away, alongside AmeriCares. “Until now, we’ve waited for an invitation from the World Health Organization or Unicef or the local medical authorities to come in,” said Mark Pietroni, the center’s medical director. “That’s sometimes six weeks late.”
This is increasingly the future of disaster management: prepositioning to get what’s needed to where it’s needed earlier. Instead of buying and shipping food stocks after a crisis begins, for example, the United States Agency for International Development and the World Food Program are increasingly buying food during harvests, when it is cheaper, and storing it near potential crisis zones, much of it in W.F.P.’s huge warehouse in Mombasa, Kenya.
Bangladesh is famous for its nongovernmental organizations — the Grameen Bank and the anti-poverty giant BRAC are the most widely known. But the Center for Diarrheal Disease has achieved just as much. The center invented oral rehydration solution, a packet of salt and sugar that mothers can mix with clean water and give to a child with diarrhea. That packet saves the lives of some three million children a year.
Despite its name, the center works on a lot of problems — nutrition, H.I.V. and reproductive health, to cite a few. At its headquarters in the Dhaka, the Bangladeshi capital, it has trained more than 27,000 people from 78 countries. At its main field site in the subdistrict of Matlab, about 30 miles from Dhaka, the center has been collecting demographic data for more than 40 years. Interviews with a population that is now about 250,000 have provided researchers with key information: for example, the fact that 63 percent of child deaths are because of diseases preventable with vaccination. The results of the center’s health research in the area guide programs that have significantly reduced child mortality around the globe.
But in Bangladesh, the center is known as the Cholera Hospital. During the cholera season the center treats 1,000 people a day. “Cholera is a Bengali disease, coming from the Ganges delta,” Mr. Pietroni said. “The treatment is also a Bengali treatment.”
The center has redesigned and been an evangelist for the cholera cot — a cot made of a plastic tarp with a hole in the middle and a bucket that goes beneath. Without such cots, doctors and nurses in cholera wards find themselves wading through pools of infectious stool. And center’s staff have traveled to epidemics around the world, training local health officials, doctors and nurses.
Their most important message is the importance of early and massive hydration — if a patient is too weak to drink, then IV solution is necessary. “The biggest mistake is that patients do not get enough hydration fast enough,” Mr. Pietroni said. “You have to give huge amounts of IV fluid in the first three hours — seven or eight liters. In Dhaka at the end of April you see people with IVs in each arm and leg. But as soon as the patient can drink, you switch them to oral rehydration.”
Flooding patients produces Lazarus-like effects. People who come in barely showing a pulse are sitting up and drinking just a few hours later. This September, in the midst of an outbreak in Somalia, two doctors and a nurse from the center gave a five-day cholera course in Mogadishu. “They did have an outbreak, but conditions in Somalia are really ripe for a really large, Haiti-scale outbreak, and it hasn’t happened so far,” said Gregory Anderson, a program officer for the Conrad Hilton Foundation, which gave a grant to AmeriCares and the center to provide training and supplies in Somalia and Kenya.
AmeriCares and the center realized they needed each other during their work in Haiti. “AmeriCares had the capacity to send things, but sometimes lacked the expertise,” said Alejandro Cravioto, the executive director of the center. “And when groups like us arrive, sometimes we have enough to work with, and sometimes we don’t. This was an obvious fit.”
In many cholera outbreaks, AmeriCares is already there: 70 percent of the disasters they respond to are water-related, like floods and tsunamis, and cholera usually follows two or three weeks later. Now, as soon as cholera is suspected, AmeriCares will ask a local partner to invite the Center for Diarrheal Disease. The center’s job is to confirm that the disease is cholera, work with a hospital to set up a treatment clinic — often a tent on the grounds — and, most important, train local medical personnel. AmeriCares handles the logistics: “We’d work with the ministry of health to get duty-free clearances,” said Ella Gudwin, vice president for emergency response. “We’d look at the generator, the supply chain, the availability of materials, where the water is coming from.”
AmeriCares and the Center for Diarrheal Disease are employing an idea — a preventive, proactive approach to disaster — that is starting to get attention. The project was highlighted as particularly promising at the Clinton Global Initiative meeting in 2011. “This has definitely not been philanthropy’s role in the past,” said Mr. Anderson of the Hilton Foundation. “It’s been a very reactive sector. But we’re very focused on it. The return on investment is much better.”
Join Fixes on Facebook and follow updates on twitter.com/nytimesfixes.

Tina Rosenberg won a Pulitzer Prize for her book “The Haunted Land: Facing Europe’s Ghosts After Communism.” She is a former editorial writer for The Times and now a contributing writer for the paper’s Sunday magazine. Her new book is “Join the Club: How Peer Pressure Can Transform the World.”
An earlier version of this article incorrectly stated that the cholera cot was invented by icddr,b. While the organization has popularized its use, it did not invent the cot.



21 Comments
Click here to read the best Times comments from the past week.
Leslie Wetter
Portland April 11, 2012This may be going off topic but could the U.S. also be hit one day? During that time will there be an Americare mission for our homeless? Will there be a health program that would allow free immunization? When the poor are hit the wealthy are endangered as well.
In this scenario my belief is our homeless would be the first hit. There afterwards who else? America gets so many other world diseases due to our history of immigration. Because of this we should keep free health care in cases such as these. Universities must train our college medical students on how to handle such epidemics. This might be another reason not to vote for those against cost free emergency medical care. Consider this food for thought.
MI April 12, 2012
My understanding is that the chances for a cholera outbreak in the US are low because of our modern sewage and water treatment facilities. Even the homeless have access to those. Most cases in this country are caused by travelers returning from abroad. If there were to be a major outbreak, it would probably start there.
JimBob
Colorado April 11, 2012During a trip to Tanzania and Kenya a couple years ago, my wife got cholera. (She was undergoing chemotherapy for ovarian cancer so our I.D. specialist advised against immunization.) She was saved due to the efforts of a local doctor who closed his clinic, rushed to our hotel and advised us NOT to go to the local hospital. ("People go there to die.")
He then commanded that the hotel employees drive a nail into the fancy hotel room wall so he could hang an IV bag. She was weak as a kitten after 2 days but felt better. Still had the problem when we returned to Colorado where we were treated as minor celebrities ("Cholera?? Really?? Neat!!")
Guess my point is, if you can get immunized before you travel, DO IT! I had the oral Vivotif Berna stuff and never had a problem. Simple disease to treat, but it killed a lot of our ancestors here in the U.S. during the western migration.
Jim
Graupel
WA April 11, 2012Two other benefits of cholera beds- they free up staff to some degree in crises, and more importantly, allow fluid loss to be gauged.
Dowla
Maryland April 11, 2012Speaking of synergy--the first thing Grameen Bank staff does during a flood is distribute ORS to the borrowers to save them from Cholera
ellen
Brooklyn April 11, 2012Partners In Health is also doing important work (for decades now) in combating cholera in Haiti. They've trained thousands of health care workers and plan on introducing an oral cholera vaccine this year.
aksantacruz
Santa Cruz, CA April 11, 2012I have been working in Haiti since the earthquake to introduce compost sanitation and compost toilets to contain and treat human excreta through high heat composting. Simple compost toilets and on-site composting can dramatically reduce the spread of disease. Children walk bare foot in their own feces and women cook and clean with contaminated water. In Haiti, people defecate and wash themselves in the same polluted rivers. Human waste runs through open sewers and spreads through the environment during the rainy season. Without a large-scale effort to protect water resources and prevent fecal contamination of the environment in large slums and rural areas, diarrheal diseases will flourish.
The current vaccination in effort in Haiti will only reach about 100,000 people - a fraction of the at-risk population. The largest slum in Port-au-Prince has over 300,000 inhabitants. In the rural areas, large populations live isolated from health care facilities. The cost of the cholera response has cost hundreds of millions of dollars and yet nothing is being spent to develop appropriate improved sanitation systems.
Open defecation is a major cause of disease, premature death in children, and environmental and water pollution. There needs to be a holistic approach to improving public health and medical community needs to look beyond emergency response, hygiene training, and vaccinations as a cure all.
vklip
Pennsylvania April 11, 2012I heard a report on NPR in the last couple of weeks that said, in essence, that it has been very difficult to move through the Haitian bureaucracy to get permission to administer the vaccine. The report was about a group working in the area which appears to be the epicenter of the outbreak of cholera in Haiti (allegedly brought in by someone from one of the UN disaster relief teams). According to the report, cholera was not common in Haiti before the earthquake. Persons interviewed in the report said that they have the vaccine, they have people qualified to administer it, they have permission slips/requests from hundreds or thousands of people, but they have not been given permission by the Haitian government to begin the program.
I understand that the vaccine does not give immunity for more than a few years, but it could prevent thousands of cases in the near future, giving time to put the sanitation measures into place.
Dr. Anna Nagurney
Massachusetts April 11, 2012This semester I am teaching a new course, Humanitarian Logistics and Healthcare, at the Isenberg School of Management at UMass Amherst. In this course, we have recently been discussing the importance of the timely delivery of critical needs products (water, food, medicines, and vaccines) in times of disasters to the victims as well as the teaming of organizations for resource sharing. We have also been learning about the importance of prepositioning supplies and are using supply chain network formalisms to assess where the locations should be.
Thanks for this article that shows two strategies for disaster management in action -- the teaming of organizations as well as effective relief chain management through the prepositioning supplies in "optimal" locations.
This is another article from The New York Times that we will be discussing in my class, as we did the expertly written recent investigative one on the spread of cholera in Haiti post the earthquake.
Dr. David Egilman
mass April 11, 2012This is NOT prevention. Prevention would be defined by providing bacteria free water to PREVENT the occurrence of any cases.
www.ghets.org
ASA
Dhaka, Bangladesh April 9, 2012To respond to SS: immunization for cholera is still at an early stage.
The original cholera vaccine, Dukoral, is available for travellers in the developed countries, but are not affordable for a mass scale vaccination campaign in the developing world. The newer and more affordable alternative, ShanChol, is yet to be certified by the WHO for mass use. More importantly, the 2-3 year immunity period provided by the vaccine is not sufficient to effectively immunize the hundreds of millions of people in vulnerable countries, when global production of such vaccines are only hovering at a few million doses per year.
So, to make immunization work, there has to be a massive global scale effort to ramp up production and administer aggressively in the developing world. But this will need significant resource commitments - knowing the immunity will only last a few years - this is unlikely to happen.
The next hope would be the discovery of a new vaccine that has a longer immunity period and a cost that is affordable to the masses. The Gates Foundation is putting a lot of resources behind this and we may see a positive outcome sometime soon. But to make the research find its way to application for a mass vaccination program could still take years!
ASA
Dhaka, Bangladesh April 9, 2012Thank you for highlighting the work of ICDDR,B who have been tirelessly saving lives for the past half a century in Bangladesh and in diarrheal hotspots around the globe in recent emergencies.
However, to make "a preventive, proactive approach to disaster" truly effective, we need to dive deeper into the environmental and hydro-climatic origins of cholera outbreaks and increase our ability to respond even faster with the help of climate based prediction. Recent discoveries suggest a strong role of hydroclimatic and environmental drivers of epidemic cholera outbreaks, such as droughts in spring cholera, and floods in fall cholera in Bangladesh. The availability and variability of freshwater, which is largely modulated by climatic forces, can directly affect the ability to provide safe water and sanitation access (which is vital to stop the spread of diseases such as cholera) as well as the progression of contamination and cholera outbreaks from one community to another.
Thus, new generation research has to be integrated with established prevention measures and make the global community's response more effective with prediction aided prevention. As some of the earlier posters have correctly pointed out, cholera is entirely preventable. However, we need to know, as much in advance as possible, where the next outbreak will strike. With prediction, "proactive" prevention can be made "preemptive" and save lives early and during outbreaks.
Peter Lorber
California April 9, 2012Thank you for an excellent piece on cholera. A trivial point for the record--- the ICDDRB has done lots of wonderful things, but inventing the cholera bed is not among them. The cholera bed had been around at least as early as the mid-19th century, and is described in many medical reports. I know this because during the cholera epidemic in East Africa during the 1998-1999 El Nino, while working with Medecins sans Frontieres, I did much searching of old reports for tips I could in my program.
Peter Lorber
(former logistics coordinator, MSF)
Jumper
is a trusted commenter South Carolina April 8, 2012I'm glad to read how these organizations are working together to respond to cholera outbreaks with necessary speed.
However, this is outrageous. Dr. John Snow demonstrated the connection between fecal contaminated water and cholera in 1854. In the 1870s, slow sand filters, were proven to reduce water borne epidemics. Rapid sand filters, with higher operating costs. were developed in the 1880s. Coupled with water chlorination to disinfect the water, it was shown that potable-water spread of cholera and typhoid fever was stopped in its tracks by 1913.
That was 100 years ago. Cholera is entirely preventable. Cholera and typhoid fever are both the result of sewage, (fecal), contamination of water ending up in our mouths.
When sewerage removal infrastructure and potable water distribution infrastructure are destroyed, the diseases, especially cholera, are soon to follow. Yet, the relief agencies in Haiti acted surprised. They shouldn't have been.
We should have immediately put in place an abundance of potable water centers and had a reporting network for the first symptoms of cholera. Warning signs for a population that can't read aren't effective.
Fecal contamination isn't only third world. In the U.S. we call it e-coli contamination. If journalists were honest and called it fecal contamination, we'd be outraged, demanding to know how our food became fecal contaminated, and demanding an end to the practices that endanger the food of our entire population.
SS
C April 8, 2012Why was no mention made about immunization as a preventive?
Jon D
NM April 8, 2012Cholera is one of *the* most dangerous of diseases historically speaking.
Cholera is also both preventable and curable.
But neither prevention or treatment is the problem.
The problem, if one is interested, is that millions of people have neither access to clean drinking water nor medical care...and never will.
Tina Rosenberg
is an NYTimes reporter Author, Fixes April 11, 2012To Jon D and also Jumper:
Of course you are right. Clean water supply and sanitation are the most basic preventive measures. There are few goals more worthy than providing these things – they would not only prevent cholera, but many other water-borne diseases.
Astonishingly, there has been great progress on this front. One of the Millennium Development Goals was reducing by half the number of people in the world who do not have access to clean drinking water. That goal has been met -- well ahead of the 2015 deadline. At the end of 2010, 89 percent of the world had access to "improved" drinking water, and that number should rise to 92 percent by 2015.
89 percent might sound pretty good -- but the 11 percent of the world that still drinks microbe soup is nearly 800 million people. Nor has the world made progress on the companion goal -- providing sanitation. And as the Fixes column often notes, it is much easier to install water pumps than to keep them going. More than a third of hand pumps stop working in their first few years, and most will never be repaired.
Clean water and sanitation for the world is at best a long-term goal, more likely a fantasy. Until then, we will have cholera, and more and more of it as the planet warms. So it is important to head off epidemics by coming in early with the proper tools and measures.
Laughingdragon
SF Bay Area April 8, 2012Why didn't you include the formula for oral rehydrating fluid?
It is 18 grams sugar, 3 grams salt to one litre of water.
That is 6 level measured teaspoons of sugar, 1 level teaspoon of salt and one litre of water.
Tina Rosenberg
is an NYTimes reporter Author April 11, 2012Laughingdragon,
Thank you for this. However, every recipe I've seen says to use 1/2 teaspoon of salt -- not one teaspoon -- per liter of water and 6 tsp sugar. It should be no saltier than tears. Too much salt is harmful to a child.
Now there is an alternative to sugar -- rice-based oral rehydration solution. Studies, including those carried out by the icddr,b, have shown that ORS made with 15 teaspoons of rice flour per liter instead of the sugar is as effective or more effective than sugar-based ORS.
It was important to find an alternative because in Bangladesh, sugar is available to poor people only seasonally and is very expensive. They found that all grain-based ORS worked well, but rice was the least likely to cause allergies.
Diana
Oklahoma City, OK July 16, 2012Both laughingdragon and Tina are trying to be internet experts on a subject they obviously dont know very well. You cant read an 10 minute internet synopsis of cholera and oral rehydration solution and then come on here and pretend you know whats going on.
First off, all oral rehydration solution, regardless of whether it's simple glucose or complex carb rice based has "sugar" in it. By definition, ORS = sugar content. ORS wont work at all without sugar in it because the co-transporter required for intestinal villae absorption of salt and water requires glucose as a co-factor. Carbohydrates = sugar. Rice starch-based ORS gets broken down into glucose molecules which are required by the intestinal villae as co-factors to absorb salt and water. Rice-based ORS have the advantage of lower osmolarity which enhances osmotic pull of H20 from the lumen of the intestines to the interstitial space.
Secondly, the magic number for salt-containing oral-rehydration solutions to ensure optimum spacing of water from the intralumenal to the interstitial space according to the American Academy of Pediatrics is 70-90 meq/L. Depending on the exact formulation of salt you are using, both 1/2 and 1 teaspoon will get you in that ballpark. At any rate, neither dose will cause excess osmolarity or excess renal solute loads that Tina is worried about. Children (even neonates) will be fine with either 1/2 or 1 tsp of salt.
Ann
is a trusted commenter California April 8, 2012Astonishing to read about this rise in cholera, when it seemed at one point a disease of the past. I recall in the 1970s when America funded a lot of projects abroad to get clean water and sanitation to people. Now the need for sanitation and a quick response is so much more critical. I am grateful to read more about what's happening, particularly the efforts of groups like AmeriCares and the Center for Diarrheal Disease to stop and reduce the possibility of outbreaks before they happen. For the many brave souls working on the front lines. Thank you.
21 Comments
Click here to read the best Times comments from the past week.